1414 iPotential sources of new histamine-producing cells in the skin of patients with atopic dermatits

We have investigated the expression and localization of histidine decarboxylase (HDC, a key enzyme for histamine biosynthesis) in human skin by immunohistochemical analysis. HDC-immunoreactive cytokeratin 14-non immunoreactive cells were observed around basal layer epidermis healthy subjects patients with atopic dermatitis (AD). These did not express mast cell-tryptase but expressed tyrosinase microphthalmia-associated transcription factor. Moreover, HDC mRNA proteins detected cultured normal epidermal melanocytes, suggesting that are melanocytes. Furthermore, 10-non also suprabasal layers AD, which CD1a, these Langerhans cells. In addition, we found was sweat glands AD levels its higher than subjects. studies, presumed cells, themselves can produce histamine, potential new sources chronic inflammations, such as AD.